Protein Name: F-box/LRR-repeat protein 15
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UniprotKB/SwissProt ID: FXL15_HUMAN (Q9H469)
Gene Name: FBXL15
Synonyms: FBXO37
Organism: Homo sapiens (Human).
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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