UniprotKB/SwissProt ID: FZR_HUMAN (Q9UM11)
Gene Name: FZR1
Synonyms: CDH1, FYR, FZR, KIAA1242
Organism: Homo sapiens (Human).
Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 2: Nucleus. Isoform 3: Cytoplasm.
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