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Protein Name: E3 ubiquitin-protein ligase HECTD1

UniprotKB/SwissProt ID: HECD1_HUMAN (Q9ULT8)

Gene Name: HECTD1

Synonyms: KIAA1131

Organism: Homo sapiens (Human).

Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000569
IPR002110
IPR008979
IPR010606
IPR011989
IPR012919


The ubiquitination sites of HECD1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1229DPAPLA K HGLTEE CCCCCC C CCCCHH 45.98%21890473
2255GPSSAC K PGRSTT CCCCCC C CCCCCC 50.66%20639865
3461LRDEDG K TPLDKA CCCCCC C CHHHHH 60.33%21906983
4466GKTPLD K ARERGH CCCHHH H HHHCCC 57.96%21906983
5522MAPIYL K RLLPVF HHHHHH H CCCCCC 24.83%21890473
6736RARGQV K PSTSSQ HHHCCC C CCCCCC 25.93%21906983
7947ERINVF K TAFSEN HHHHHH H HHHCCC 34.36%21906983
81272VRSQVL K YMVPGA CCCCHH H HHHHCC 32.23%21890473
91287IRGLDW K WRDQDG CCCCCC C CEECCC 31.83%21890473
101500VSELTN K EAASQR CCCCCC C CCCCCC 43.42%21906983
111754EEEYET K GGRRRT CCCCCC C CCCCCC 47.64%21906983
121768DDDYVL K RQFSAL CCCCCC C CCCHHC 33.82%21890473
131919LITYLQ K NADAAF HHHHHH H HHCCCH 52.05%21890473
141981DILNLT K EQPQAK CCCHHH H HHCCCC 58.48%21906983
152268VDLPIS K PFFKLM EEEEEE C CHHHHH 46.71%21890473
162364RFLKEI K DLAIKR HHHHHH H HHCCCC 48.02%21890473
172471FRDGFN K VFPMEK HHHHHH H HHHCCH 42.88%2190698

The interacting network mediated by proteins: HECD1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes