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Protein Name: Probable E3 ubiquitin-protein ligase HERC1

UniprotKB/SwissProt ID: HERC1_HUMAN (Q15751)

Gene Name: HERC1

Organism: Homo sapiens (Human).

Function: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin- rich surface protrusions.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of HERC1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
12769SLRQIA K AMEATG   50.31%21890473
22881AVTRRH K FDLAAR   38.47%21890473
33311DDSIQR K FLPSFL   34.57%21890473
43460VWNVTK K QYSLQQ   45.14%21890473
54468KTMVQG K NYGPQI   29.88%2189047
The interacting network mediated by proteins: HERC1_HUMAN

Disease:
Disease database Database Entry Disease information
OMIM605109HECT DOMAIN AND RCC1-LIKE DOMAIN 1; HERC1 ;;P532
Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.