logo
   Home | Network Analysis | Data Statistics | Quick Search by Swiss-Prot ID or Keyword

Menu:


Protein Name: Probable E3 ubiquitin-protein ligase HERC4

UniprotKB/SwissProt ID: HERC4_HUMAN (Q5GLZ8)

Gene Name: HERC4

Synonyms: KIAA1593

Organism: Homo sapiens (Human).

Function: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000408
IPR000569
IPR009091


The ubiquitination sites of HERC4_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1218FGWGRN K FGQLGL EEEECC C CCCCCC 49.89%21906983
2469ARLLFH K LIQPDH HHHHHH H HHCCCC 39.69%21890473
3488VAASLE K NLIPKL HHHHHH H HHHHHH 63.45%21890473
4493EKNLIP K LTSSLP HHHHHH H HCCCCC 58.36%21890473
5890ADTAVN K QNRQEF CCCCCC H HHHHHH 42.21%890473

The interacting network mediated by proteins: HERC4_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes