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Protein Name: Probable E3 ubiquitin-protein ligase HERC6

UniprotKB/SwissProt ID: HERC6_HUMAN (Q8IVU3)

Gene Name: HERC6

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000408
IPR000569
IPR009091


The ubiquitination sites of HERC6_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1276YSPTPE K RGPQLV CCCCCC C CCCEEC 64.95%21906983
2404TEHEMA K SEIRMI CCCCCC C CCEEEE 47.51%21906983
3798PSLEDL K ELSPRL CCHHHH H HCCHHH 69.77%21906983
4806LSPRLG K SLQEVL CCHHHH H HHHHHH 53.22%21906983
5916QFEQNS K YEQGYQ HHHHHC C CCCCCC 61.43%2190698

The interacting network mediated by proteins: HERC6_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes