UniprotKB/SwissProt ID: HLTF_HUMAN (Q14527)
Gene Name: HLTF
Synonyms: HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1
Organism: Homo sapiens (Human).
Function: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus. Nucleus, nucleolus (By similarity). Nucleus, nucleoplasm (By similarity). Note=Nuclear localization is stimulated by progesterone (By similarity).
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