UbiNet

Protein Name: E3 ubiquitin-protein ligase HUWE1

UniprotKB/SwissProt ID: HUWE1_HUMAN (Q7Z6Z7)

Gene Name: HUWE1

Synonyms: KIAA0312, KIAA1578, UREB1

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells.

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR000449
IPR000569
IPR003903
IPR004170
IPR009060
IPR010309
IPR010314
IPR015940

The ubiquitination sites of HUWE1_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	324	KQLMEI K AASLRT	CCHHHH H HHHHHH	25.29%		21890473
2	632	PFERLF K VLLSPD	HHHHHH H HHCCHH	36.24%		21890473
3	674	RHQPTL K TDATTA	HHCCCC C HHHHHH	47.00%		21890473
4	1050	ARIKQI K PLLSAS	HHHHHH H HHHHHH	27.41%		21890473
5	1107	TASALT K LLTKGL	HHHHHH H HHHHHH	42.20%		21890473
6	1111	LTKLLT K GLSWQP	HHHHHH H HHCCCC	58.80%		21890473
7	1147	MLFDER K YPYHLM	EEECCC C CHHHHH	48.83%		21890473
8	1225	PHSLPA K LPGGVQ	CCCCCC C CCCCCC	53.96%		21890473
9	1247	FLVVTQ K AAFTCI	HHHHHH H HHHHHH	32.11%		21906983
10	1295	ERLSKE K EGSRGE	HHHCCC C CCCCCC	71.73%		21906983
11	1608	RRAQMT K YLQSNS	HHHHHH H HHHCCC	38.32%		21890473
12	1693	RLNKNS K NSNGQE	CCCCCC C CCCHHH	74.02%		21906983
13	1702	NGQELE K TLEESK	CHHHHH H HHHHCC	71.66%		21890473
14	1708	KTLEES K EMDIKR	HHHHHC C CCCCCC	61.41%		21906983
15	1718	IKRKEN K GNDTPL	CCCCCC C CCCCCC	61.25%		21906983
16	1733	ESTNTE K ETSLEE	HCCHHH H CCCCCH	65.34%		21906983
17	1799	MMFAEL K STRMIL	HHHHHC C CCHHHH	41.09%		21906983
18	1840	LRHTME K VVRSAA	HHHHHH H HHHHHH	34.90%		21906983
19	1917	FENLRI K GPNAVQ	EEEEEE C CCCCCC	62.98%		21890473
20	1926	NAVQLV K TTPLKP	CCCCCC C CCCCCC	56.10%		21890473
21	1931	VKTTPL K PSPLPV	CCCCCC C CCCCCC	44.65%		21890473
22	2218	IIRLFL K KGLVND	HHHHHH H CCCHHH	37.14%		21906983
23	2219	IRLFLK K GLVNDL	HHHHHH C CCHHHH	60.67%		21906983
24	2248	TVNAAL K PLETLS	HHHHHH H HHHHHH	42.71%		21890473
25	2267	SSLFGS K SASSKN	HHHHHC C CHHHHC	50.88%		21890473
26	2695	RREKRR K QLAEEE	HCCCCC C CCCCCC	54.41%		21906983
27	2703	LAEEET K ITDKGK	CCCCCC C CCCCCC	47.06%		21906983
28	3244	LCIETP K LTTSEE	HHHCCC C CCCHHH	66.92%		21906983
29	3345	TLIQLA K VFPSHF	HHHHHH H HHHHHH	53.66%		20639865
30	3452	SSLLTE K LLRLLS	CCCCHH H HHHHHH	47.81%		21890473
31	3558	GSKSPA K VSDGGS	CCCCCC C CCCCCC	45.73%		21906983
32	3621	TRDTVL K LLLNGA	HHHHHH H HHHHHH	32.52%		21890473
33	3636	LGYTLC K QIGTLL	HHHHHH H HHHHHH	48.33%		21906983
34	3697	VIVASQ K RPLGGR	EEEECC C CCCCCC	54.19%		21890473
35	3835	GTPQGE K EKEERP	CCCCCC C CCCCCH	79.50%		21906983
36	3912	SQLAHI K DEPPPL	HHHHHH H HCCCCC	46.29%		21890473
37	3954	LPPDTQ K FLRFAE	CCCCCC C CCHHHH	48.75%		21890473
38	4116	VGRIVA K AVYDNR	HHHHHH H HHHCCE	27.73%		21906983
39	4190	CEVRDL K PNGANI	CEEEEE C CCCCCC	40.50%		21906983
40	4295	DQADRA K FLQFVT	CHHHHH H HHEEEC	47.72%		21890473
41	4305	FVTGTS K VPLQGF	EECCCC C CCHHHH	47.94%		21890473
42	4322	GMNGIQ K FQIHRD	CCCCCC E EEEECC	37.00%		2189047

The interacting network mediated by proteins: HUWE1_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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