UniprotKB/SwissProt ID: KAT2B_HUMAN (Q92831)
Gene Name: KAT2B
Synonyms: PCAF
Organism: Homo sapiens (Human).
Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (By similarity).
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PDB :
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