UniprotKB/SwissProt ID: KDM2B_HUMAN (Q8NHM5)
Gene Name: KDM2B
Synonyms: CXXC2, FBL10, FBXL10, JHDM1B, PCCX2
Organism: Homo sapiens (Human).
Function: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus.
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