UniprotKB/SwissProt ID: KEAP1_HUMAN (Q14145)
Gene Name: KEAP1
Synonyms: INRF2, KIAA0132, KLHL19
Organism: Homo sapiens (Human).
Function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
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PDB :
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