UniprotKB/SwissProt ID: KLH42_HUMAN (Q9P2K6)
Gene Name: KLHL42
Synonyms: KIAA1340, KLHDC5
Organism: Homo sapiens (Human).
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase c
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