UniprotKB/SwissProt ID: KLHL2_HUMAN (O95198)
Gene Name: KLHL2
Organism: Homo sapiens (Human).
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection (By similarity). Cell projection, lamellipodium (By similarity). Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over- expressed, colocalizes with NPTXR
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PDB :
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