UbiNet

Protein Name: Lipopolysaccharide-induced tumor necrosis factor-alpha factor

UniprotKB/SwissProt ID: LITAF_HUMAN (Q99732)

Gene Name: LITAF

Synonyms: PIG7, SIMPLE

Organism: Homo sapiens (Human).

Function: Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with membranes of lysosomes.

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR006629

The ubiquitination sites of LITAF_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	159	ALLGTY K RLxxxx	EEEEEE E CC	47.24%		2113904

The interacting network mediated by proteins: LITAF_HUMAN

Disease:

Disease database	Database Entry	Disease information
KEGG	H00264	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
OMIM	601098	CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1C; CMT1C ;;CMT, SLOW NERVE CONDUCTION TYPE
OMIM	603795	LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; LITAF ;;LPS-INDUCED TNF-ALPHA
HPRD	10354	Charcot-Marie-tooth disease, type 1c

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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