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Protein Name: Leucine-rich repeat protein 1

UniprotKB/SwissProt ID: LLR1_HUMAN (Q96L50)

Gene Name: LRR1

Synonyms: PPIL5

Organism: Homo sapiens (Human).

Function: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001611


The ubiquitination sites of LLR1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
172IEQFFT K FVDEGK HEEEEE C CCCCCC 37.93%21906983
278KFVDEG K ATVRLK CCCCCC C CCCCCE 38.55%2190698

The interacting network mediated by proteins: LLR1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes