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Protein Name: E3 ubiquitin-protein ligase LRSAM1

UniprotKB/SwissProt ID: LRSM1_HUMAN (Q6UWE0)

Gene Name: LRSAM1

Synonyms: TAL

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001611
IPR001660
IPR001841
IPR004825
IPR010993
IPR011510
IPR013761


The ubiquitination sites of LRSM1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1491LTQLEL K RKSLDT HHHHHH H HHCCCH 48.70%21890473
2520LLQQLL K EKQQRE HHHHHH H HHHHHH 72.03%21906983
3564QKPLSL K LQEEGM CCCCEE E EHHHHH 44.76%2189047

The interacting network mediated by proteins: LRSM1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes