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Protein Name: Mitogen-activated protein kinase kinase kinase 1

UniprotKB/SwissProt ID: M3K1_HUMAN (Q13233)

Gene Name: MAP3K1

Synonyms: MAPKKK1, MEKK, MEKK1

Organism: Homo sapiens (Human).

Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000719
IPR001841
IPR002290
IPR007527
IPR008271
IPR011009
IPR013083
IPR015749

The ubiquitination sites of M3K1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
11398AARLAS K GTGAGE EECCHH H CCHHHH 55.68%2190698
The interacting network mediated by proteins: M3K1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.