Protein Name: E3 ubiquitin-protein ligase MARCH4
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UniprotKB/SwissProt ID: MARH4_HUMAN (Q9P2E8)
Gene Name: MARCH4
Synonyms: KIAA1399, RNF174
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane; Multi-pass membrane protein.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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