UniprotKB/SwissProt ID: MARH6_HUMAN (O60337)
Gene Name: MARCH6
Synonyms: KIAA0597, RNF176, TEB4
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
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