Protein Name: Mediator of RNA polymerase II transcription subunit 8
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UniprotKB/SwissProt ID: MED8_HUMAN (Q96G25)
Gene Name: MED8
Organism: Homo sapiens (Human).
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (Probable).
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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