UniprotKB/SwissProt ID: MIB2_HUMAN (Q96AX9)
Gene Name: MIB2
Synonyms: SKD, ZZANK1
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.
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