UniprotKB/SwissProt ID: MKRN1_HUMAN (Q9UHC7)
Gene Name: MKRN1
Synonyms: RNF61
Organism: Homo sapiens (Human).
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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