UniprotKB/SwissProt ID: NED4L_HUMAN (Q96PU5)
Gene Name: NEDD4L
Synonyms: KIAA0439, NEDL3
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Note=May be recruited to exosomes by NDFIP1.
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