UniprotKB/SwissProt ID: NEUL1_HUMAN (O76050)
Gene Name: NEURL1
Synonyms: NEURL, NEURL1A, RNF67
Organism: Homo sapiens (Human).
Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein (By similarity). Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). No
| |
|
