UniprotKB/SwissProt ID: NHLC1_HUMAN (Q6VVB1)
Gene Name: NHLRC1
Synonyms: EPM2B
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
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