UniprotKB/SwissProt ID: NIPA_HUMAN (Q86WB0)
Gene Name: ZC3HC1
Synonyms: NIPA
Organism: Homo sapiens (Human).
Function: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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