Protein Name: E3 ubiquitin-protein ligase pellino homolog 3
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UniprotKB/SwissProt ID: PELI3_HUMAN (Q8N2H9)
Gene Name: PELI3
Organism: Homo sapiens (Human).
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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