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Protein Name: Protein phosphatase 1D

UniprotKB/SwissProt ID: PPM1D_HUMAN (O15297)

Gene Name: PPM1D

Synonyms: WIP1

Organism: Homo sapiens (Human).

Function: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000222
IPR001932
IPR014045
IPR015655


The ubiquitination sites of PPM1D_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
119SDQGGR K YMEDVT CCCCCH H HHHHHH 52.83%21906983
2238GGSVMN K SGVNRV CCCEEE C CCCCEE 30.41%21890473

The interacting network mediated by proteins: PPM1D_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes