UbiNet

Protein Name: Rab5 GDP/GTP exchange factor

UniprotKB/SwissProt ID: RABX5_HUMAN (Q9UJ41)

Gene Name: RABGEF1

Synonyms: RABEX5

Organism: Homo sapiens (Human).

Function: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Early endosome. Recycling endosome.

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR002653
IPR003123
IPR013995

The ubiquitination sites of RABX5_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	263	QSLTFS K FEEKKT	HHHHHH H HHHHCC	53.24%		21890473
2	267	FSKFEE K KTNEKT	HHHHHH H CCCCCC	58.67%		21906983
3	280	RKVTTV K KFFSAS	CCCEEE E CCCCCC	41.59%		21906983
4	281	KVTTVK K FFSASS	CCEEEE C CCCCCC	47.51%		21890473
5	299	KEIQEA K APSPSI	HHHHHC C CCCCCC	61.14%		21906983
6	318	ETDRVS K EFIEFL	HHHHHH H HHHHHH	54.51%		21890473
7	325	EFIEFL K TFHKTG	HHHHHH H HHHHHH	55.24%		21890473
8	329	FLKTFH K TGQEIY	HHHHHH H HHHHHH	50.59%		21890473
9	339	EIYKQT K LFLEGM	HHHHHH H HHHHHH	34.45%		21906983
10	348	LEGMHY K RDLSIE	HHHHHH H HCCCCH	25.43%		21890473
11	423	PPERVE K IMDQIE	CHHHHH H HHHHHH	40.24%		21890473
12	520	HIFNAI K ITKNEP	HHHHHH C CCCCCC	41.74%		21890473
13	629	GVKQMY K NLDLLS	HHHHHH H HHHHHH	45.77%		21890473

The interacting network mediated by proteins: RABX5_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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