UbiNet

Protein Name: E3 ubiquitin-protein ligase RAD18

UniprotKB/SwissProt ID: RAD18_HUMAN (Q9NS91)

Gene Name: RAD18

Synonyms: RNF73

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity).

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR001841
IPR003034
IPR006642
IPR013083

The ubiquitination sites of RAD18_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	83	ILDELV K SLNFAR	HHHHHH H HHHHHH	62.95%		21890473
2	102	ALESPA K SPASSS	HHCCCC C CCCCCC	61.43%		21890473
3	110	PASSSS K NLAVKV	CCCCCC C CCCCCC	58.91%		21906983
4	115	SKNLAV K VYTPVA	CCCCCC C CCCCCC	24.74%		21890473
5	151	TSELLI K ENKSKF	CCCHHC C CHHHHH	56.03%		21890473
6	161	SKFSPQ K EASPAA	HHHHHH H HHHHCC	59.64%		21890473
7	168	EASPAA K TKETRS	HHHHCC C CHHHHH	63.34%		21906983
8	186	PDPSEA K RPEPPS	CCCCCC C CCCCCH	65.52%		21890473
9	197	PSTSTL K QVTKVD	CHHHHC C CCCCCC	42.69%		20639865
10	218	PESHIN K HLDSCL	CHHHHH H HHHHHC	44.96%		21890473
11	245	KRKPLP K TVYNLL	CCCCCC C EEHHHC	59.30%		21890473
12	257	LSDRDL K KKLKEH	CCCHHH H HHHHHC	52.75%		21906983
13	261	DLKKKL K EHGLSI	HHHHHH H HCCCCC	57.45%		21890473
14	271	LSIQGN K QQLIKR	CCCCCC H HHHHHH	46.36%		21890473
15	309	EIENIE K TRMRLE	HHHHHH H HHCCCC	37.32%		20639865
16	318	MRLEAS K LNESVM	CCCCCC C CCCCEE	63.48%		20639865
17	328	SVMVFT K DQTEKE	CEEECC C CCCHHH	36.05%		21890473
18	333	TKDQTE K EIDEIH	CCCCCH H HHHHHH	64.46%		21906983
19	347	KYRKKH K SEFQLL	HHHHHH H HHHHHH	61.64%		21906983
20	370	IAGMSQ K TVTITK	HHHCCC C CCCCCC	37.34%		21890473
21	376	KTVTIT K EDESTE	CCCCCC C CCCCCC	60.36%		21906983
22	462	AWEASH K NDLQDT	HHHHHH H CCCCCC	50.06%		2190698

The interacting network mediated by proteins: RAD18_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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