UniprotKB/SwissProt ID: RBBP5_HUMAN (Q15291)
Gene Name: RBBP5
Synonyms: RBQ3
Organism: Homo sapiens (Human).
Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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PDB :
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