UbiNet

Protein Name: E3 SUMO-protein ligase RanBP2

UniprotKB/SwissProt ID: RBP2_HUMAN (P49792)

Gene Name: RANBP2

Synonyms: NUP358

Organism: Homo sapiens (Human).

Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments.

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR000156
IPR001440
IPR001876
IPR002130
IPR011990
IPR011993
IPR013026
IPR015891

The ubiquitination sites of RBP2_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	94	ELNPTQ K DLVLKI	HCCCCH H HHHHHH	56.35%		21906983
2	354	DKIIEL K DLVMGT	HHHHCC C CCEEEE	27.56%		21906983
3	379	VETFAN K SGQSAL	HHHHHC C CCHHHH	53.16%		21906983
4	405	QKNKLL K GIDLGS	CCCCCC C CCCCCC	53.01%		21906983
5	464	LDDAKV K DEPDSP	HHHHHH C CHHHHH	3.30%		21906983
6	579	TFWRHR K QADLDL	HHHHHH H HHHHHH	5.24%		21906983
7	660	GFEDEA K TSARDA	EEEEHH H CCCHHH	10.60%		21906983
8	817	AIESLV K PQAKKK	HHHHHH H HHHHHH	30.52%		21906983
9	907	KVERIP K ALEVTE	CCCCCC C CCCHHC	39.41%		21906983
10	989	RTALWQ K QASASQ	CCCCCC C CCCCCC	18.40%		21906983
11	1067	RTTQST K HGEVDA	CCCCCC C CCCCCC	6.73%		21906983
12	1115	AARTLE K VGDRRS	EEEECC C CCCCCC	4.48%		2190698
13	2125	LEQLAA K FKTPEL	EEEEEE E CCCHHH	41.61%		21890473
14	2396	MTLQNM K GTERVW	CEEEEC C CCCEEE	70.95%		21890473
15	2522	FGSESV K SIFSSE	ECCHHH H HHHHCC	47.30%		21890473
16	2935	DEEILF K ERAKLY	HHHHHH H CCCEEE	42.73%		21906983
17	2959	RGVGDI K ILWHTM	CCCEEE E EECCCC	36.16%		2189047

The interacting network mediated by proteins: RBP2_HUMAN

Disease:

Disease database	Database Entry	Disease information
OMIM	601181	RAN-BINDING PROTEIN 2; RANBP2 ;;NUP358
OMIM	608033	ENCEPHALOPATHY, ACUTE NECROTIZING 1, SUSCEPTIBILITY TO; ANE1

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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