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Protein Name: Rho-related BTB domain-containing protein 3

UniprotKB/SwissProt ID: RHBT3_HUMAN (O94955)

Gene Name: RHOBTB3

Synonyms: KIAA0878

Organism: Homo sapiens (Human).

Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000210
IPR011333
IPR013069


The ubiquitination sites of RHBT3_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1105KYNVND K FSFHEV EEECCC H HHHHHH 37.39%21890473
2120NYIPVI K RALNSV HHHHHH H HHCCCC 31.67%21890473
3366DIRKKL K DSGDVS HHHHHH H HHCCHH 59.74%21906983
4377VSNVIE K VKCILK HHHHHH H HCCCCC 35.55%21906983
5538DIVDLL K KAKFHH HHHHHH H HHHHCC 58.96%21906983
6592PSNMYL K QLAEYR CHHHHH H HHHHHH 26.27%2189047

The interacting network mediated by proteins: RHBT3_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes