UniprotKB/SwissProt ID: RN111_HUMAN (Q6ZNA4)
Gene Name: RNF111
Organism: Homo sapiens (Human).
Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
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PDB :
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