UniprotKB/SwissProt ID: RN128_HUMAN (Q8TEB7)
Gene Name: RNF128
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys- 48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recy
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