UbiNet

Protein Name: E3 ubiquitin-protein ligase RNF216

UniprotKB/SwissProt ID: RN216_HUMAN (Q9NWF9)

Gene Name: RNF216

Synonyms: TRIAD3, UBCE7IP1, ZIN

Organism: Homo sapiens (Human).

Function: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of RN216_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	100	QTEREP K PGPSHN		58.83%		21906983
2	351	ASQDET K LPKIDF		61.82%		21906983
3	362	DFFDYS K LTPLDQ		50.59%		21906983
4	391	LSSQDI K WALHEL		34.40%		21890473
5	425	SPETSG K RKKRKQ		61.89%		21906983
6	485	QEFYEQ K IKEMAE		43.75%		21906983
7	584	PQTILY K YYERKA		37.60%		21890473
8	666	RTSIEE K MTAARI		28.85%		21906983
9	765	NGENTF K RIGPPL		40.86%		21906983
10	773	IGPPLE K PVEKVQ		63.14%		2190698

The interacting network mediated by proteins: RN216_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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