Protein Name: E3 ubiquitin-protein ligase RLIM
|
UniprotKB/SwissProt ID: RNF12_HUMAN (Q9NVW2)
Gene Name: RLIM
Synonyms: RNF12
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
| |
|
Graphical Visualization of Ubiquitination Sites:
|
| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
|
