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Protein Name: E3 ubiquitin-protein ligase RNF14

UniprotKB/SwissProt ID: RNF14_HUMAN (Q9UBS8)

Gene Name: RNF14

Synonyms: ARA54

Organism: Homo sapiens (Human).

Function: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000608
IPR001841
IPR002867
IPR006058
IPR006575


The ubiquitination sites of RNF14_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1372QADEAN K RLLDQR CCHHHH H HHHHHH 52.01%21906983
2386GKRVIQ K ALEEME HHHHHH H HHHHHH 43.76%21890473

The interacting network mediated by proteins: RNF14_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes