Protein Name: E3 ubiquitin-protein ligase RNF6
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UniprotKB/SwissProt ID: RNF6_HUMAN (Q9Y252)
Gene Name: RNF6
Synonyms: SPG2
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cell projection, axon (By similarity). Nucleus, PML body (By similarity). Note=Localizes to the PML nuclear bodies in Sertoli cells (By similarity).
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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