Protein Name: E3 ubiquitin-protein ligase SHPRH
|
UniprotKB/SwissProt ID: SHPRH_HUMAN (Q149N8)
Gene Name: SHPRH
Synonyms: KIAA2023
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
| |
|
Graphical Visualization of Ubiquitination Sites:
|
| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
|
