UniprotKB/SwissProt ID: SMUF1_HUMAN (Q9HCE7)
Gene Name: SMURF1
Synonyms: KIAA1625
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
|
PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
