UniprotKB/SwissProt ID: SOCS4_HUMAN (Q8WXH5)
Gene Name: SOCS4
Synonyms: SOCS7
Organism: Homo sapiens (Human).
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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