UniprotKB/SwissProt ID: SOCS6_HUMAN (O14544)
Gene Name: SOCS6
Synonyms: CIS4, SOCS4
Organism: Homo sapiens (Human).
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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