UbiNet

Protein Name: Spartin

UniprotKB/SwissProt ID: SPG20_HUMAN (Q8N0X7)

Gene Name: SPG20

Synonyms: KIAA0610, TAHCCP1

Organism: Homo sapiens (Human).

Function: May be implicated in endosomal trafficking, or microtubule dynamics, or both.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Transiently associated with endosomes.

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR007330

The ubiquitination sites of SPG20_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	29	AFLFVN K GLNTDE	HHHHHH H HHCHHH	60.52%		21890473
2	47	EAKNYY K QGIGHL	HHHHHH H HHHHHH	31.52%		473
3	62	GISISS K ESEHTG	CEEEEE E CCCCCC	59.47%		21890473
4	82	QMQQKM K ETLQNV	HHHHHH H HHHHHH	55.36%		21890473
5	362	PSSDQL K EASGTD	CCCCCC C CCCCCC	45.67%		18781797
6	362	PSSDQL K EASGTD	CCCCCC C CCCCCC	45.67%		18781797
7	362	PSSDQL K EASGTD	CCCCCC C CCCCCC	45.67%		18781797
8	370	ASGTDV K QLDQGN	CCCCCH H HHHCCC	48.21%		21890473
9	377	QLDQGN K DVRHKG	HHHCCC H HHHHHC	65.51%		21890473
10	440	VSWGLV K GAEITG	HHHHHH C CCCCCH	58.40%		21906983
11	465	RIQPEE K PVEVSP	HCCCCC C CEEECC	53.34%		21890473
12	475	VSPAVT K GLYIAK	ECCHHH H CEEEEE	40.08%		21890473
13	578	VQTVRY K YGYNAG	HHHHHH H HCCCCC	22.95%		2189047

The interacting network mediated by proteins: SPG20_HUMAN

Disease:

Disease database	Database Entry	Disease information
HPRD	06170	Spastic paraplegia 20, autosomal recessive

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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