UniprotKB/SwissProt ID: TBL1R_HUMAN (Q9BZK7)
Gene Name: TBL1XR1
Synonyms: IRA1, TBLR1
Organism: Homo sapiens (Human).
Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (Probable).
| |
|
