UniprotKB/SwissProt ID: TLE1_HUMAN (Q04724)
Gene Name: TLE1
Organism: Homo sapiens (Human).
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Nuclear and chromatin- associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
|
PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
