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Protein Name: Transducin-like enhancer protein 2

UniprotKB/SwissProt ID: TLE2_HUMAN (Q04725)

Gene Name: TLE2

Organism: Homo sapiens (Human).

Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001680
IPR005617
IPR009146
IPR011046
IPR015943


The ubiquitination sites of TLE2_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1691WFVSTG K DNLLNA EEEEEE C CCEEEE 43.46%2189047

The interacting network mediated by proteins: TLE2_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes