logo
   Home | Network Analysis | Data Statistics | Quick Search by Swiss-Prot ID or Keyword

Menu:


Protein Name: E3 ubiquitin-protein ligase Topors

UniprotKB/SwissProt ID: TOPRS_HUMAN (Q9NS56)

Gene Name: TOPORS

Synonyms: LUN, TP53BPL

Organism: Homo sapiens (Human).

Function: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001841
IPR013083

The ubiquitination sites of TOPRS_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
173IMASAA K EFKMDN HHHHHC C HHHHHH 64.50%21906983
283MDNFSP K AGTSKL HHHHCC C CCCHHH 59.24%83
388PKAGTS K LQQTVP CCCCCH H HHHHCC 50.59%21906983
4249DERSLR K IQEQDI HHHHHH H HHCCCC 54.77%2190698
The interacting network mediated by proteins: TOPRS_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
Version 1.0
© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.