Protein Name: Short transient receptor potential channel 4-associated protein
|
UniprotKB/SwissProt ID: TP4AP_HUMAN (Q8TEL6)
Gene Name: TRPC4AP
Synonyms: C20orf188, TRRP4AP
Organism: Homo sapiens (Human).
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
| |
|
Graphical Visualization of Ubiquitination Sites:
|
| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
|
