UniprotKB/SwissProt ID: TRAF7_HUMAN (Q6Q0C0)
Gene Name: TRAF7
Synonyms: RFWD1, RNF119
Organism: Homo sapiens (Human).
Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
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